Antioxidative enzymes and increased oxidative stress in depressive women.

نویسندگان

  • Jana Kodydková
  • Lucie Vávrová
  • Miroslav Zeman
  • Roman Jirák
  • Jaroslav Macásek
  • Barbora Stanková
  • Eva Tvrzická
  • Ales Zák
چکیده

OBJECTIVES To investigate the activities of the main antioxidative enzymes and oxidative stress in women with depressive disorder (DD). METHODS In 35 drug-naive women with DD and 35 age matched healthy women enzymes superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPX1), glutathione reductase (GR) and paraoxonase (PON1), concentrations of conjugated dienes (CD), reduced glutathione (GSH) and anthropometric and clinical data were investigated. RESULTS Women with DD were found to have decreased activities of GPX1 (p<0.05), decreased concentrations of GSH (p<0.05), and increased activities of GR (p<0.05), CuZnSOD (p<0.001), and concentrations of CD (p<0.05). Activity of GPX1 was positively correlated with concentration of GSH (p<0.05). Concentrations of CD were positively correlated with TG (p<0.01). CONCLUSION Our set of depressive women was characterized by changes indicating an increased oxidative stress, as well as by certain features of metabolic syndrome.

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عنوان ژورنال:
  • Clinical biochemistry

دوره 42 13-14  شماره 

صفحات  -

تاریخ انتشار 2009